NICE Guideline 206 – ME/CFS (October 2021)


This page provides links to resources from the 25% ME Group aimed at busy professionals who are looking for a rapid, concise and brief overview of core points from NG206, including what has changed.

Published 29 October 2021, this guideline concerns ‘ME/CFS: diagnosis and management’ and reflects a sea change in the recommended approach to healthcare.

Our resources incorporate a specific focus on the care of people with severe and very severe ME.


Links to download 25% ME Group resources follow the descriptions below


NG 206: Core Guidance, with focus on severely affected patients – Key extracts from the guideline, with a focus on the care and support of severely and very severely affected ME/CFS patients. Coverage includes: recognising distinctive clinical picture; symptoms and activity/sensory stimulus (post-exertional malaise or symptom exacerbation); adjustments to facilitate access to services; gastrointestinal problems and nutritional support; facilitating aids and adaptations; prescribing. (2022; 4 pages)

This is suitable for both health and social care professionals, however those working in social care may prefer the shorter version specifically on implications for social care, listed below.

NG 206: Guidance for social care professionals – Core guidance from NG206 as it relates to social care. Coverage includes: ways in which severe and very severe ME can impact on care needs; approach to care assessment and delivery; rationale for a flexible approach that avoids deterioration due to sensory overload. (2022; 2 pages)

See also our social care resources webpage:

The guideline and related documents can be found on the National Institute for Health and Care Excellence (NICE) website:

An appraisal of the impact on NHS workforce and resources was published on 12th May 2022:

This coincided with an announcement from the secretary of state for health and social care [Statement UIN HCWS23]: