Byron Hyde – Understanding Myalgic Encephalomyelitis – The new polio and chronic fatigue syndromes.
Dr Hyde has released 2 chapters of this new book which has been delayed as per editing and finishing details which you can find here:
https://docs.wixstatic.com/ugd/5b307e_06f1c3f9d3bb41539f9fde712e739c8b.pdf
The following is a summary of the book.
The Clinical Diagnosis of M.E. Item 1: Who Falls Ill with M.E.?
There has been considerable discussion concerning that approximately 80% of patients who fall ill with Myalgic Encephalomyelitis are females. There has been less talk about who falls ill. In my experience of investigating well over 1000 M.E. patients over the past thirty years, among adult patients are included:
* a disproportionately large number of, nurses, physicians, psychologists, social workers and other health care workers, particularly women.
* teachers, often those with students with hand, foot and mouth disease (an enteroviral disease) and other undiagnosed entero-viral infections.
* post-pubertal students who consistently burn the candle at both ends, living exhausting life styles and who tend to be in constant contact with infectious disease.
* professional women who are often working well past exhaustion and are essentially doing two jobs, particularly if they have school children at home–and the children are in contact with other enterovirus-carrying school students.
The preponderance of teachers and health care workers are female, with added home duties often including children. If the teachers have a prior autoimmune intolerance, due either to history or non-stop exhausting work plus home duties that run down their immune systems they may be more illness intolerant. Tus it is understandable that up to 80% of M.E. patients are women. Also, I have the opinion
women may tend to be more bound by rules, one of which is to receive all appropriate immunizations.
Immunization certainly protects patients from the targeted diseases, but not against other infections occurring at the same time as they receive immunizations. In my experience prevalence of M.E. among professions also depends upon the catchment area. Government towns, for example, have a large number of bureaucratic workers. Chronic Fatigue Syndrome patients do not necessarily demonstrate the same occupational characteristics. I believe their numbers generally lean to a more male than female distribution, but CFS also includes professions, with work and activities that are male-oriented.
During the 1990s many patients still had a relative, parent or grandparent, uncle, or cousin who had experienced poliomyelitis. Despite the fear it generated, unlike tuberculosis at its apex, polio was not that common. It caused me to wonder whether patients with Myalgic Encephalomyelitis have a genetic sensitivity to enteroviruses.
Dr. Alberto Marinacci, who had taken charge of the 1934 Los Angeles County General Hospital staff and had himself fallen ill with M.E. during the epidemic, but who had recovered, told me the way to encourage the onset of M.E. was to give a series of immunizations to an exhausted health care worker or teacher, who was leaving the next day on a holiday, where they would be in contact with crowds in a bus or plane and, due to the immunization, had a short term compromised immune system. No one going on a holiday by plane or bus, particularly to a third world country, where they are likely to contact novel infectious elements, should receive any immunization, unless it is 30 days prior to departure. (See the British Government publication in The Lancet in 1956.1 ). For physicians who don’t believe this association, the 1956 Lancet journal is essential reading.
If these 2 chapters are any indication, then this book is jammed packed with much information based on science and experience.
https://docs.wixstatic.com/ugd/5b307e_06f1c3f9d3bb41539f9fde712e739c8b.pdf
As shown in this book, M.E. and polio are both the result of micro-vascular injuries, (probably autoimmune and inflammatory), which damages essential neurological systems. Both are enteroviral injuries but the essential polio injury is to the vascular system of the brain stem and spinal cord, with a secondary injury to the brain as shown on the cover of this book.
M.E. and paralytic polio are in some ways mirror images. M.E. is the result of an injury to specific areas of the vascular system of the brain and cerebellum, and probably also a secondary vascular injury to the spinal cord. Except for location, this is not unlike paralytic polio where there is a vascular injury, primarily to the spinal cord and secondary injury to the brain. In other words, M.E. could be considered a form of non -paralytic poliomyelitis, as illustrated on the cover. M.E. appears to be the same as what was once referred to as missed poliomyelitis. M.E. occurred together with the early paralytic polio epidemics.
The Onset Phase of M.E. Early Confirmation of M.E. :
- Only during the first phase, as in polio or acute flaccid paralysis, is proof of enteroviral infection easily documented by raising titres or recovery of the actual virus.
- Positive oligoclonal banding may be documented if the lumbar puncture is done in the frst week of illness. Oligoclonal banding demonstrates and is consistent with neuronal injury in the anterior temporal lobe. 60 Understanding Myalgic Encephalomyelitis, The New Polio & The Chronic Fatigue Syndromes
- Abnormal brain SPECT scan can be observed in the frst day of the clinical disease and these SPECT changes remain chronically present as seen on Segami oasis SPECT software.
Note: “Only in this early phase is there a reasonable chance of potential remedial action. It is very important that physicians recognize M.E. during the first phase, because it may be the only time treatment may abort the second and chronic phase. Unfortunately, enteroviral titres are no longer available or covered by the health plans in many provinces and various American states. This is major bureaucratic stupidity, leading to a failure to categorize both M.E. and the New Polio (Acute Flaccid Paralysis) patients in North America and Europe. Since no effective treatment has ever been developed to stop or alter the vasculitis in either poliomyelitis or M.E. the only partially effective treatment is total bed rest, as suggested by Silas Weir Mitchell in the 1870s. Governments should support significant research in initial vascular treatment for polio and M.E, and research in general enteroviral immunization.” The onset phase can last up to a week.
M.E.’s Second or Chronic Phase Note: In the chronic forms of M.E. described below, one of the physician’s major roles, if they cannot significantly assist the patient, is above all to protect the patient from the avarice of the insurance industry by assisting the patient in obtaining their disability pension. Patients or physicians may become aware of the symptoms.
14 Cascading Manifestations of M.E.: In addition to the persistence of chronic findings – particularly (a) the persisting rapid decay of intellectual and cognitive stamina, (b) the loss of physical stamina (endurance) following modest physical, intellectual or emotional activity, and (c) the unusually slow recovery following physical, intellectual or emotional exertion –any of the following abnormalities,
(which may indicate a CNS deregulatory injury), can be anticipated to develop in M.E. patients. I include only the most frequently observed relatively common findings.
Multiple social injuries, marital discord and separation, suicide and poverty from patients exhaustingly searching for a cure or a knowledgeable physician.
The causes are (a) incessant hope that an alternative medicine will help, unfortunately a few are dangerous and few are more than Band-Aid helpful, (b) incessant and expensive search for a physician who will promise recovery, (c) social disruption due to insurance companies that refuse or resist paying patients’ disability insurance pension, and (d) insurance companies that do not allow partially recovered
patients to return to work part-time and receive partial compensation. They then, often want the patient to return to full time work or resign. If at all possible such work accommodation should be made to these patients. Most M.E. patients don’t wish to be excluded from a normal work life.
Sectioning: This is a cruel technique employed by the authorities and some physicians in the UK. Sectioning refers to the separation of M.E. children from their parents and their incarceration in psychiatric institutes or hospitals, where they were often placed in a PACE trial on psychiatric medications since it is falsely assumed these patients are psychiatric patients. Deaths have been associated. Years ago, Dr. Michael Cohen, Pediatrician of Tarzana, near Los Angeles, believed some of the street children he had seen were simply abandoned M.E. children.
Post-M.E. Syndrome:
Twenty-five to thirty-five years after falling ill, as if chronic M.E. illness was not bad enough, approximately a fifth of all M.E. patients have a worsening of their clinical disease. This condition is best described by Gareth Williams, Emeritus Professor of Medicine at Bristol University, in his extremely well researched book on polio, Paralyzed With Fear. Williams is actually describing post-polio-syndrome (PPS); however, this is exactly what is happening to one in five of my older M.E. patients.
I could not better describe the condition occurring in some older M.E. patients than in the following description, extracted from Dr. Gareth Williams’ book,
Paralysed With Fear (page 35). His description of post polio syndrome is identical to that of post-M.E. Syndrome. Williams describes it as follows:
“The cardinal features of PPS are the new onset of muscular weakness, pain and fatigue, together with physical and mental tiredness affecting the whole body. Sometimes there is deep burning pain and tenderness over tendons and other “trigger points”. A flu-like exhaustion can be permanent and debilitating. Symptoms usually develop insidiously and are often made worse by exertion. The diagnosis rests solely on the patient’s account of his or her symptoms and can be contentious. There are no distinguishing physical signs, nor any laboratory tests, which can distinguish these changes. Since two of the symptoms, anxiety and disturbed sleep, are common in older people they are often dismissed. The impact of PPS is highly variable, as is the way it is perceived by the medical profession. Some authorities dismiss PPS as an indolent condition. This view might not be shared by the many who coped well for 20-30 years after falling ill, but who now can no longer climb the stairs, or run their homes.
” The Reputed CFS PACE Treatment: There can be no treatment for Chronic Fatigue Syndrome in any patient without first discovering the cause of the disability obscured by the term CFS. As repeatedly mentioned, there are multiple totally different pathological causes of CFS, therefore potentially multiple totally different treatments depending on the cause of the patient symptoms, a few of which are malignancies.
Reading Michael Sharpe, Kim Goldsmith and Trudie Chalder’s publication: The PACE trial of Treatments for Chronic Fatigue Syndrome, one would believe PACE is an accepted treatment of CFS . Their publication begins with the following statement, and I quote:
“Chronic Fatigue Syndrome (CFS) is a chronic disabling illness…”
In this statement, the authors shy away from calling CFS either a disease or a syndrome. Yet CFS is not a disease, not really a syndrome either because CFS clearly represents what is probably well over 100 pathologies or diseases. If the treatment were as banal as a sugar tablet, it wouldn’t be so bad. However, at the patient’s insistence, I placed one of the senior Nursing Directors in Ottawa, whose physicians had her diagnosed CFS, into the equivalent of a PACE trial for GET, or graded exercise therapy. I didn’t believe in this so I hospitalized her in the excellent Ottawa Rehabilitation Hospital for a month and let the specialists
perform this “patient insisted” service. This graded exercise not only resulted in a disaster, but she had walked into the hospital and came home in an ambulance and ended up for subsequent years in total bed and house confinement. I and her physicians exacerbated her already severe injury by agreeing to her request. My experience with CBT, Cognitive Behavior Therapy has been equally disastrous. Insurance companies regularly send patients with “CFS” for such combined treatment. The result in every one of my patients subjected to this treatment is they are made, not only worse, but when they are forced to leave the program, the insurance companies then stop paying their client their disability pension. The Insurance Company rational: Non-compliance with the treatment programme. I wonder if insurance companies either intentionally or unintentionally “salt the mine,” by placing a minor or non-illness patient in a PACE program who then miraculously gets better.
Advanced orders are now being accepted through the Nightingale Research Foundation website, http://www.nightingale.ca
Other Publications
The Nightingale Definition of Myalgic Encephalomyelitis (M.E.)download for free
https://docs.wixstatic.com/ugd/5b307e_b3a662c05f174937b9516d473a994c41.pdf
The Terrible Tale of Amy Brown
This story is about a lovely nine year old schoolgirl who lives with her family in an amazing andsometimes turbulent country called England. It once had one of the best public health systems in theworld. It is still a country full of good and kind people and great physicians, but sometimes physiciansare too busy and miss important illnesses. This is such a story. Down load for free
https://docs.wixstatic.com/ugd/5b307e_1f2ab80503974be084d77d6070efbd3a.pdf
The Clinical and Scientific Basis of Myalgic Encephalomyelitis-
Edited by Byron Hyde, M.D. -Nightingale Research Foundation, Ottawa, Canada
with editorial and conceptual advice from Paul Levine, M.D., NIH, Bethesda, Maryland, USA and Jay Goldstein, M.D., Chronic Fatigue Syndrome Institute, USA,
- Published by Nightingale Research Foundation simultaneously in Canada and the USA, 1992.
https://www.dropbox.com/s/zik0o5oyauru3rp/Chronic%20Fatigue%20Syndrome.compressed.pdf?dl=0
Missed Diagnoses -Dr. Hyde’s 2010 book, “Missed Diagnoses” is available either in printed format, or electronic format via download.
Paperback Edition: http://www.lulu.com/shop/byron-hyde-md/missed-diagnoses-myalgic-encephalomyelitis-chronic-fatigue-syndrome-second-edition/paperback/product-18463888.html
e-book:
