Papers By The 25% M.E Group Patrons, Trustees & Advisers
Purpose This page explains neuroimmune dysfunction in Myalgic Encephalomyelitis (M.E.), focusing on how abnormalities in the brain, immune system, autonomic nervous system, and circulation interact to produce the characteristic symptoms of the disease. Key Points 1. Neuroimmune Dysfunction Overview M.E. involves a disruption between the nervous system and immune system The body becomes stuck in…
Purpose This page explains Post-Exertional Neuroimmune Exhaustion (PENE), the defining feature of Myalgic Encephalomyelitis (M.E.) according to the International Consensus Criteria. It outlines what PENE is, how it presents, and why it is central to understanding and diagnosing the disease. Key Points 1. Definition of PENE PENE is the core and defining feature of M.E.%20%20in%20ME.pdf)…
Purpose This page summarises findings from research reviewing urinary biomarkers in Myalgic Encephalomyelitis (M.E./ME/CFS). It explains whether urine-based testing can identify consistent biological patterns and support diagnosis, while outlining current limitations. Key Points 1. Overall Findings There is no single validated urinary biomarker for M.E. However, research shows repeated patterns of metabolic disruption Findings suggest…
Purpose This page explains how people with Myalgic Encephalomyelitis (M.E.) can identify and manage their personal activity baseline. It outlines the importance of pacing, understanding individual limits, and preventing symptom worsening caused by overexertion. Key Points 1. What is an Activity Baseline An activity baseline is the level of physical, cognitive, and sensory activity a…
Purpose This page provides an expanded overview of Myalgic Encephalomyelitis (M.E.) based on detailed clinical descriptions. It explains the core nature of the disease, its defining features, and the wide range of neurological, autonomic, immune, and systemic symptoms affecting multiple body systems. Key Points 1. Overview of M.E. M.E. is a distinct neurological disease recognised…
Purpose This page provides a structured overview of the wide range of symptoms associated with Myalgic Encephalomyelitis (M.E.) as defined by the International Consensus Criteria. It aims to help patients, carers, and professionals understand the complexity of the illness and its multi-system impact. Key Points 1. Understanding M.E. M.E. is a serious multi-system neurological disease…
Purpose This page explains the relationship between Fibromyalgia (FM) and Myalgic Encephalomyelitis (M.E.), highlighting where the conditions overlap, how they differ, and why they are often confused or diagnosed together. Key Points 1. Overview of Each Condition Fibromyalgia (FM): Primarily a pain-focused condition Characterised by widespread musculoskeletal pain and sensitivity Myalgic Encephalomyelitis (M.E.): A multi-system…
Purpose This page explains swallowing difficulties (dysphagia) in Myalgic Encephalomyelitis (M.E.), including the possible causes, symptoms, methods of assessment, and approaches to management. It highlights how dysphagia can arise from the multi-system dysfunction seen in M.E. Key Points 1. What is Dysphagia in M.E. Difficulty swallowing is a recognised symptom in some people with M.E….
Purpose This page provides an overview of Myalgic Encephalomyelitis (M.E.) as defined by the International Consensus Criteria (ICC 2011). It highlights the multi-system nature of the disease, with a focus on cardiovascular involvement, symptom patterns, and principles of management. Key Points 1. M.E. as a Multi-System Disease M.E. is a complex neuroimmune disease, not simply…
Purpose This page explains why many people with Myalgic Encephalomyelitis (M.E.) struggle to receive proper diagnosis, recognition, and medical care. It outlines the historical, systemic, and cultural factors that have contributed to the dismissal and under-treatment of the condition. Key Points 1. Historical Misclassification Early outbreaks of M.E. were documented as a neurological illness Later…